:a-diagram-of-a-breast-tumor-with-a-mix-of-cells:

:draw-a-diagram-of-a-breast-tumor-with-a-mix-of-cells.-use-different-colors-or-shapes-to-represent-the-phenotypically-diverse-populations-of-breast-cancer-cells.:

:نموداری-از-تومور-سینه-با-ترکیبی-از-سلول-ها-را-رسم-کنید.-از-رنگ-ها-یا-اشکال-مختلف-برای-نشان-دادن-جمعیت-های-متنوع-از-نظر-فنوتیپی-سلول-های-سرطان-سینه-استفاده-کنید.:

:reast-cancer-is-the-most-common-malignancy-in-united-states-women,-accounting-for->40,000-deaths-each-year.-these-breast-tumors-are-comprised-of-phenotypically-diverse-populations-of-breast-cancer-cells.-using-a-model-in-which-human-breast-cancer-cells-were-grown-in-immunocompromised-mice,-we-found-that-only-a-minority-of-breast-cancer-cells-had-the-ability-to-form-new-tumors.-we-were-able-to-distinguish-the-tumorigenic-(tumor-initiating)-from-the-non-tumorigenic-cancer-cells-based-on-cell-surface-marker-expression.-we-prospectively-identified-and-isolated-the-tumorigenic-cells-as-cd44+cd24—/lowlineage—-in-eight-of-nine-patients.-as-few-as-100-cells-with-this-phenotype-were-able-to-form-tumors-in-mice,-whereas-tens-of-thousands-of-cells-with-alternate-phenotypes-failed-to-form-tumors.-the-tumorigenic-subpopulation-could-be-serially-passaged-each-time-cells-within-this-population-generated-new-tumors-con-taining-additional-cd44+cd24—/lowlineage—-tumorigenic-cells-as-well-as-the-phenotypically-diverse-mixed-populations-of-nontumorigenic-cells-present-in-the-initial-tumor.-the-ability-to-prospectively-identify-tumorigenic-cancer-cells-will-facilitate-the-elucidation-of-pathways-that-regulate-their-growth-and-survival.-furthermore,-because-these-cells-drive-tumor-development,-strategies-designed-to-target-this-population-may-lead-to-more-effective-therapies.:

:reast-cancer-is-the-most-common-malignancy-in-united-states-women,-accounting-for->40,000-deaths-each-year.-these-breast-tumors-are-comprised-of-phenotypically-diverse-populations-of-breast-cancer-cells.-using-a-model-in-which-human-breast-cancer-cells-were-grown-in-immunocompromised-mice,-we-found-that-only-a-minority-of-breast-cancer-cells-had-the-ability-to-form-new-tumors.-we-were-able-to-distinguish-the-tumorigenic-(tumor-initiating)-from-the-non-tumorigenic-cancer-cells-based-on-cell-surface-marker-expression.-we-prospectively-identified-and-isolated-the-tumorigenic-cells-as-cd44+cd24—/lowlineage—-in-eight-of-nine-patients.-as-few-as-100-cells-with-this-phenotype-were-able-to-form-tumors-in-mice,-whereas-tens-of-thousands-of-cells-with-alternate-phenotypes-failed-to-form-tumors.-the-tumorigenic-subpopulation-could-be-serially-passaged-each-time-cells-within-this-population-generated-new-tumors-con-taining-additional-cd44+cd24—/lowlineage—-tumorigenic-cells-as-well-as-the-phenotypically-diverse-mixed-populations-of-nontumorigenic-cells-present-in-the-initial-tumor.-the-ability-to-prospectively-identify-tumorigenic-cancer-cells-will-facilitate-the-elucidation-of-pathways-that-regulate-their-growth-and-survival.-furthermore,-because-these-cells-drive-tumor-development,-strategies-designed-to-target-this-population-may-lead-to-more-effective-therapies.:

:reast-cancer-is-the-most-common-malignancy-in-united-states-women,-accounting-for->40,000-deaths-each-year.-these-breast-tumors-are-comprised-of-phenotypically-diverse-populations-of-breast-cancer-cells.-using-a-model-in-which-human-breast-cancer-cells-were-grown-in-immunocompromised-mice,-we-found-that-only-a-minority-of-breast-cancer-cells-had-the-ability-to-form-new-tumors.-we-were-able-to-distinguish-the-tumorigenic-(tumor-initiating)-from-the-non-tumorigenic-cancer-cells-based-on-cell-surface-marker-expression.-we-prospectively-identified-and-isolated-the-tumorigenic-cells-as-cd44+cd24—/lowlineage—-in-eight-of-nine-patients.-as-few-as-100-cells-with-this-phenotype-were-able-to-form-tumors-in-mice,-whereas-tens-of-thousands-of-cells-with-alternate-phenotypes-failed-to-form-tumors.-the-tumorigenic-subpopulation-could-be-serially-passaged-each-time-cells-within-this-population-generated-new-tumors-con-taining-additional-cd44+cd24—/lowlineage—-tumorigenic-cells-as-well-as-the-phenotypically-diverse-mixed-populations-of-nontumorigenic-cells-present-in-the-initial-tumor.-the-ability-to-prospectively-identify-tumorigenic-cancer-cells-will-facilitate-the-elucidation-of-pathways-that-regulate-their-growth-and-survival.-furthermore,-because-these-cells-drive-tumor-development,-strategies-designed-to-target-this-population-may-lead-to-more-effective-therapies.: