:create-a-vector-illustration-depicting-the-complex-origins-of-liver-cancer-stem-cells-(liver-cscs).-the-illustration-should-include-the-following-elements-a-representation-of-the-liver-with-hepatocytes-and-hepatic-progenitor-cells-(hpcs)-to-show-the-cellular-hierarchy-and-the-quiescent-state-of-hpcs-in-the-canal-of-hering.-visual-metaphors-for-the-differentiation-arrest-model,-showing-hpcs-arrested-in-development-due-to-aberrant-wnt/β-catenin-signaling,-leading-to-stem-like-properties.-illustrations-of-dedifferentiation-and-transdifferentiation-processes,-where-mature-hepatocytes-revert-to-a-stem-like-state-or-transform-into-different-cell-types,-influenced-by-p53-loss-and-wnt/notch-pathway-mutations.-a-diagram-showing-the-role-of-extrahepatic-sources-like-bone-marrow-cells,-myeloid-lineages,-and-mesenchymal-stem-cells-(mscs)-migrating-to-the-liver-and-contributing-to-liver-cscs-via-the-cxcr4/sdf1α-axis.-a-portrayal-of-epithelial-mesenchymal-transition-(emt)-with-cells-transitioning-from-an-epithelial-to-a-more-mesenchymal-state,-marked-by-changes-in-cell-surface-markers.-a-depiction-of-cell-fusion-events-creating-hybrid-cells-with-increased-invasiveness-and-tumorigenicity,-showing-the-involvement-of-proteins-like-myomaker-and-myomerger.-metabolic-reprogramming-aspects,-emphasizing-the-maintenance-of-cancer-stemness-through-mitochondrial-fission-and-mitophagy.-a-reference-to-induced-pluripotent-stem-cell-(ipsc)-research,-showing-the-reprogramming-of-differentiated-cells-to-a-pluripotent-state,-acquiring-cancer-stem-like-properties-influenced-by-factors-like-oct4,-sox2,-klf4,-and-c-myc.-the-style-should-be-scientific-and-detailed,-suitable-for-a-medical-journal-or-textbook.-use-appropriate-color-coding-for-different-cell-types-and-pathways,-and-include-labels-for-clarity.:

:vector,-cancer-cells-in-the-liver,-white-background,-within-a-big-circle-like-a-pic-diagram-divided-into-6-parts:

:draw-a-diagram-of-a-breast-tumor-with-a-mix-of-cells.-use-different-colors-or-shapes-to-represent-the-phenotypically-diverse-populations-of-breast-cancer-cells.:

:black-and-white-silhouette-style-layout-featuring-various-christmas-themed-icons-arranged-in-a-grid.-the-top-row-includes-a-sleigh-with-santa-and-reindeer,-snowflakes,-a-reindeer-head,-and-a-gift-box.-the-middle-row-showcases-christmas-trees,-snowmen,-santa-hats,-and-santa's-face.-the-bottom-row-contains-bows,-candy-canes,-a-christmas-ornament,-a-wreath,-holly,-candles,-and-an-angel.-each-icon-is-distinct-with-clean-lines-and-simple-shapes,-emphasizing-traditional-holiday-symbols.:

:black-and-white-silhouette-style-layout-featuring-various-christmas-themed-icons-arranged-in-a-grid.-the-top-row-includes-a-sleigh-with-santa-and-reindeer,-snowflakes,-a-reindeer-head,-and-a-gift-box.-the-middle-row-showcases-christmas-trees,-snowmen,-santa-hats,-and-santa's-face.-the-bottom-row-contains-bows,-candy-canes,-a-christmas-ornament,-a-wreath,-holly,-candles,-and-an-angel.-each-icon-is-distinct-with-clean-lines-and-simple-shapes,-emphasizing-traditional-holiday-symbols.:

:vector,-cancer-cells-and-normal-cells-dividing:

:a-diagram-of-a-breast-tumor-with-a-mix-of-cells:

:guilloche-style-illustration,-white-background,-thin-black-lines,-no-grays,-image-of-a-white-blood-cell-showing-internal-parts:

:two-m-letters-with-white-background:

:guilloche-style-illustration,-white-background,-thin-black-lines,-no-grays-or-colors,-image-of-a-white-blood-cell-showing-internal-parts:

:reast-cancer-is-the-most-common-malignancy-in-united-states-women,-accounting-for->40,000-deaths-each-year.-these-breast-tumors-are-comprised-of-phenotypically-diverse-populations-of-breast-cancer-cells.-using-a-model-in-which-human-breast-cancer-cells-were-grown-in-immunocompromised-mice,-we-found-that-only-a-minority-of-breast-cancer-cells-had-the-ability-to-form-new-tumors.-we-were-able-to-distinguish-the-tumorigenic-(tumor-initiating)-from-the-non-tumorigenic-cancer-cells-based-on-cell-surface-marker-expression.-we-prospectively-identified-and-isolated-the-tumorigenic-cells-as-cd44+cd24—/lowlineage—-in-eight-of-nine-patients.-as-few-as-100-cells-with-this-phenotype-were-able-to-form-tumors-in-mice,-whereas-tens-of-thousands-of-cells-with-alternate-phenotypes-failed-to-form-tumors.-the-tumorigenic-subpopulation-could-be-serially-passaged-each-time-cells-within-this-population-generated-new-tumors-con-taining-additional-cd44+cd24—/lowlineage—-tumorigenic-cells-as-well-as-the-phenotypically-diverse-mixed-populations-of-nontumorigenic-cells-present-in-the-initial-tumor.-the-ability-to-prospectively-identify-tumorigenic-cancer-cells-will-facilitate-the-elucidation-of-pathways-that-regulate-their-growth-and-survival.-furthermore,-because-these-cells-drive-tumor-development,-strategies-designed-to-target-this-population-may-lead-to-more-effective-therapies.:

:reast-cancer-is-the-most-common-malignancy-in-united-states-women,-accounting-for->40,000-deaths-each-year.-these-breast-tumors-are-comprised-of-phenotypically-diverse-populations-of-breast-cancer-cells.-using-a-model-in-which-human-breast-cancer-cells-were-grown-in-immunocompromised-mice,-we-found-that-only-a-minority-of-breast-cancer-cells-had-the-ability-to-form-new-tumors.-we-were-able-to-distinguish-the-tumorigenic-(tumor-initiating)-from-the-non-tumorigenic-cancer-cells-based-on-cell-surface-marker-expression.-we-prospectively-identified-and-isolated-the-tumorigenic-cells-as-cd44+cd24—/lowlineage—-in-eight-of-nine-patients.-as-few-as-100-cells-with-this-phenotype-were-able-to-form-tumors-in-mice,-whereas-tens-of-thousands-of-cells-with-alternate-phenotypes-failed-to-form-tumors.-the-tumorigenic-subpopulation-could-be-serially-passaged-each-time-cells-within-this-population-generated-new-tumors-con-taining-additional-cd44+cd24—/lowlineage—-tumorigenic-cells-as-well-as-the-phenotypically-diverse-mixed-populations-of-nontumorigenic-cells-present-in-the-initial-tumor.-the-ability-to-prospectively-identify-tumorigenic-cancer-cells-will-facilitate-the-elucidation-of-pathways-that-regulate-their-growth-and-survival.-furthermore,-because-these-cells-drive-tumor-development,-strategies-designed-to-target-this-population-may-lead-to-more-effective-therapies.:

:reast-cancer-is-the-most-common-malignancy-in-united-states-women,-accounting-for->40,000-deaths-each-year.-these-breast-tumors-are-comprised-of-phenotypically-diverse-populations-of-breast-cancer-cells.-using-a-model-in-which-human-breast-cancer-cells-were-grown-in-immunocompromised-mice,-we-found-that-only-a-minority-of-breast-cancer-cells-had-the-ability-to-form-new-tumors.-we-were-able-to-distinguish-the-tumorigenic-(tumor-initiating)-from-the-non-tumorigenic-cancer-cells-based-on-cell-surface-marker-expression.-we-prospectively-identified-and-isolated-the-tumorigenic-cells-as-cd44+cd24—/lowlineage—-in-eight-of-nine-patients.-as-few-as-100-cells-with-this-phenotype-were-able-to-form-tumors-in-mice,-whereas-tens-of-thousands-of-cells-with-alternate-phenotypes-failed-to-form-tumors.-the-tumorigenic-subpopulation-could-be-serially-passaged-each-time-cells-within-this-population-generated-new-tumors-con-taining-additional-cd44+cd24—/lowlineage—-tumorigenic-cells-as-well-as-the-phenotypically-diverse-mixed-populations-of-nontumorigenic-cells-present-in-the-initial-tumor.-the-ability-to-prospectively-identify-tumorigenic-cancer-cells-will-facilitate-the-elucidation-of-pathways-that-regulate-their-growth-and-survival.-furthermore,-because-these-cells-drive-tumor-development,-strategies-designed-to-target-this-population-may-lead-to-more-effective-therapies.:

:cells-neural-ode:

:a-vector-of-two-persons-working-at-the-office-on-investments-strategies-with-a-white-background:

:vector,-digital-illustration-of-interaction-of-human-and-ai,-minimalistic,-blue-color: