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:show-a-timeline-with-key-dates-and-photos-of-howard-garns-and-maki-kaji,-who-popularized-sudoku-in-japan:
:creata-a-logo-for-a-festival-concessions-stand-called-"bedouin-bbq"-this-will-be-at-halal-ribfest-events-across-north-america.:
:creata-a-logo-for-a-festival-concessions-stand-called-"bedouin-bbq"-this-will-be-at-halal-ribfest-events-across-north-america.:
:generate-a-set-of-30-minimalist-icons-in-a-thin-line-style-representing-various-vip-related-concepts.-include-icons-for-exclusive-access,-vip-passes,-red-carpets,-luxury-services,-and-high-profile-events.-additionally,-incorporate-symbols-for-vip-lounges,-special-invitations,-premium-seating,-and-celebrity-interactions.-ensure-that-the-icons-effectively-convey-the-essence-of-vip-and-exclusive-experiences-in-a-visually-clear-and-intuitive-manner.-use-simple-and-recognizable-symbols-to-maintain-coherence-across-the-set,-emphasizing-a-consistent-design-style-and-thin-line-thickness-throughout.:
:create-a-vector-illustration-depicting-the-complex-origins-of-liver-cancer-stem-cells-(liver-cscs).-the-illustration-should-include-the-following-elements-a-representation-of-the-liver-with-hepatocytes-and-hepatic-progenitor-cells-(hpcs)-to-show-the-cellular-hierarchy-and-the-quiescent-state-of-hpcs-in-the-canal-of-hering.-visual-metaphors-for-the-differentiation-arrest-model,-showing-hpcs-arrested-in-development-due-to-aberrant-wnt/β-catenin-signaling,-leading-to-stem-like-properties.-illustrations-of-dedifferentiation-and-transdifferentiation-processes,-where-mature-hepatocytes-revert-to-a-stem-like-state-or-transform-into-different-cell-types,-influenced-by-p53-loss-and-wnt/notch-pathway-mutations.-a-diagram-showing-the-role-of-extrahepatic-sources-like-bone-marrow-cells,-myeloid-lineages,-and-mesenchymal-stem-cells-(mscs)-migrating-to-the-liver-and-contributing-to-liver-cscs-via-the-cxcr4/sdf1α-axis.-a-portrayal-of-epithelial-mesenchymal-transition-(emt)-with-cells-transitioning-from-an-epithelial-to-a-more-mesenchymal-state,-marked-by-changes-in-cell-surface-markers.-a-depiction-of-cell-fusion-events-creating-hybrid-cells-with-increased-invasiveness-and-tumorigenicity,-showing-the-involvement-of-proteins-like-myomaker-and-myomerger.-metabolic-reprogramming-aspects,-emphasizing-the-maintenance-of-cancer-stemness-through-mitochondrial-fission-and-mitophagy.-a-reference-to-induced-pluripotent-stem-cell-(ipsc)-research,-showing-the-reprogramming-of-differentiated-cells-to-a-pluripotent-state,-acquiring-cancer-stem-like-properties-influenced-by-factors-like-oct4,-sox2,-klf4,-and-c-myc.-the-style-should-be-scientific-and-detailed,-suitable-for-a-medical-journal-or-textbook.-use-appropriate-color-coding-for-different-cell-types-and-pathways,-and-include-labels-for-clarity.: